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Clinical Dialogue
& eCase Challenge
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  "Multiple Sclerosis in the Age of Enhanced Therapeutic Options"
Clinical Dialogue eCase Challenge

Clinical Dialogues are engaging, video-based roundtable discussions focusing on new guidelines, recent publications, and hot topics in patient management.  In tandem with the clinically-focused eCase Challenge, this educational activity creates a complete learning experience.

eCase Challenges are interactive, text-based case studies designed to integrate the educational objectives into day-to-day clinical practice.  The video "Clinical Pearl" summarizes key clinical aspects of this activity.

     
   
CME InfoHelp
Title:
Presented by: Johns Hopkins University School of Medicine
Release Date: February 5, 2018
Expiration Date: February 5, 2019
Estimated time to complete this activity:   60 minutes for the and 45 minutes for the .
Fees and Prerequisites There are no fees or prerequisites.
Acknowledgement of Commercial Support:  Supported by independent educational grants from Biogen and Novartis
Target Audience
This activity is intended for neurologists and other healthcare practitioners involved in the care of patients with multiple sclerosis.
Learning Objectives
After participating in this activity, the participant will demonstrate the ability to:
  • Explain the mechanisms of action of available and emerging multiple sclerosis (MS) therapies as well as implications for treatment selection.
  • Discuss the efficacy and safety of current treatments for MS and available data on investigational therapies.
  • Review perspectives on MRI and clinical findings that may prompt consideration of switching therapy for MS.
  • Analyze knowledge about MS therapies and aspects of a patient’s presentation to make an informed decision when switching MS therapies.
Presented by the Johns Hopkins University School of Medicine
Accreditation Statement
The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Credit Designation Statement
The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 1.75TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Other Credits
American Nurses Credentialing Center (ANCC) accepts TM from organizations accredited by the ACCME.
American Association of Nurse Practitioners National Certification Program accepts TM from organizations accredited by the ACCME.
American Academy of PAs (AAPA) accepts certificates of participation for educational activities certified for TMfrom organizations accredited by the ACCME. PAs may receive a maximum of 1.75 AAPA Category 1 Credits for completing this program.
Statement of Need
Despite decades of progress in the management of relapsing-remitting multiple sclerosis (RRMS), notable challenges remain. With a growing armamentarium of treatment options, clinicians are faced with the need to understand the full range of risk-benefit profiles so as to select the most appropriate therapy based on individual patient characteristics. Of particular concern are the large numbers of patients who fail to respond adequately to initial treatment with a disease-modifying therapy (DMT). Prompt recognition of such patients is crucial to prevent the accumulation of disability and delay disease progression. Clinicians must have the requisite knowledge to identify clinical and MRI findings suggestive of a suboptimal response that necessitates switching to another treatment strategy. The process of deciding which DMT should be chosen when switching therapy mandates consideration of the mode of actions, efficacy and safety, and individual patient factors. Clinicians must be competent in addressing these issues if the best possible outcomes are to be achieved. The potential advent of additional treatments also highlights the need for clinicians to stay up to date on developments that may impact the management of RRMS in the future.
Johns Hopkins Chair and Activity Director
Shiv Saidha, MBBCh, MD, MRCPI
Associate Professor of Neurology
Division of Neuroimmunology and Neurological Infections
Johns Hopkins University School of Medicine
Baltimore, Maryland
Faculty
Robert Bermel, MD
Assistant Professor of Medicine
Case Western Reserve University, School of Medicine
Director, Mellen Center for Multiple Sclerosis
Cleveland Clinic Neurological Institute
Cleveland, Ohio
Scott Newsome, DO, MSCS, FAAN
Associate Professor of Neurology
Director, Neurology Outpatient Services
Director, Neurology Infusion Center
Director, Stiff Person Syndrome Center
Member, Miller-Coulson Academy of Clinical Excellence
Division of Neuroimmunology and Neuroinfectious Diseases
Johns Hopkins University School of Medicine
Baltimore, Maryland
Policy on Speaker and Provider Disclosure
It is the policy of the Johns Hopkins University School of Medicine that the speaker and provider globally disclose conflicts of interest. The Johns Hopkins University School of Medicine OCME has established policies in place that will identify and resolve all conflicts of interest prior to this educational activity. Detailed disclosure will be made in the instructional materials.
Johns Hopkins Statement of Responsibility
The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.
Internet CME Policy
The Office of Continuing Medical Education (OCME) at the Johns Hopkins University School of Medicine is committed to protecting the privacy of its members and customers. Johns Hopkins University School of Medicine OCME maintains its Internet site as an information resource and service for physicians, other health professionals and the public. OCME at the Johns Hopkins University School of Medicine will keep your personal and credit information confidential when you participate in a CME Internet based program. Your information will never be given to anyone outside of the Johns Hopkins University School of Medicine CME program. CME collects only the information necessary to provide you with the services that you request.
Copyright
All rights reserved - The Johns Hopkins University School of Medicine. No part of this program may be used or reproduced in any manner whatsoever without written permission except in the case of brief quotations embodied in articles or reviews.
Format and Method of Participation
Review this internet-based CME activity. To take the post-test, please click on the post-test button below the video window of the player which will take you to the Johns Hopkins University School of Medicine’s website. If you already have registered for other programs at this website, simply enter the requested information when prompted. Otherwise, complete the registration form to begin the testing process. The information you enter here will be used to generate your CME certificate. Please complete all fields to ensure accurate registration. Complete the post-test and evaluation and attest to the amount of time spent in the activity. Upon receiving a score of 70% or above, print your CME certificate.
Full Disclosure Policy Affecting CME Activities
As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), Johns Hopkins University School of Medicine Office of Continuing Medical Education (OCME) requires attested and signed global disclosure of the existence of all financial interests or relationships with commercial interest from any individual in a position to control the content of a CME activity sponsored by OCME. The following relationships have been reported for this activity:
Faculty

Robert Bermel, MD – Contracted Research: Biogen Idec; Consulting Fee: Genentech, Inc., Genzyme Corporation, Novartis AG

Scott Newsome, DO, MSCS, FAAN – Contracted Research: Biogen Idec, Genentech, Inc., Novartis AG; Consulting Fee: Biogen Idec, Celgene, Genentech Inc.

Shiv Saidha, MBBCh, MD, MRCPI – Contracted Research: Genentech, Inc.; Consulting Fee: Biogen Idec, EMD Serono, Genzyme Corporation, Novartis AG; Equity: 2% JuneBrain

Note: Grants to investigators at The Johns Hopkins University are negotiated and administered by the institution which receives the grants, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).
Off-Label Discussion
The following speakers have disclosed that their presentation will reference unlabeled/unapproved uses of drugs or products:
Robert Bermel, MD, Scott Newsome, DO, and Shiv Saidha, MBBCh, MD: cladribine, high-dose biotin, ofatumumab, opicinumab, ponesimod, siponimod
Disclaimer
The opinions and recommendations expressed by faculty and other experts, whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of the Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combinations of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.
CONFIDENTIALITY DISCLAIMER FOR CME ACTIVITY PARTICIPANTS
I certify that I am participating in a Johns Hopkins University School of Medicine CME activity for accredited training and/or educational purposes.
I understand that while I am participating in this capacity, I may be exposed to "protected health information," as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the "Privacy Regulations"). Protected health information is information about a person’s health or treatment that identifies the person.
I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential. I agree not to post or discuss this protected health information, including pictures and/or videos, on any social media site (e.g. Facebook, Twitter, etc.), in any electronic messaging program or through any portable electronic device.
I understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this Confidentiality Pledge or under any of the Hopkins policies and procedures and applicable laws and regulations related to confidentiality. The contact information is: Johns Hopkins Privacy Officer, telephone: 410-735-6509, e-mail: HIPAA@jhmi.edu.
“The Office of Continuing Medical Education at the Johns Hopkins University School of Medicine, as provider of this activity, has relayed information with the CME attendees/participants and certifies that the visitor is attending for training, education and/or observation purposes only.”
For CME Questions, please contact the CME Office
(410) 955-2959 or e-mail cmenet@jhmi.edu.
For CME Certificates, please call (410) 502-9634.
Johns Hopkins University School of Medicine
Office of Continuing Medical Education
Turner 20/720 Rutland Avenue
Baltimore, Maryland 21205-2195
Reviewed & Approved by:
General Counsel, Johns Hopkins Medicine (4/1/03)
(Updated 4/09 and 3/14)
Privacy Statement/Internet Policy
The Office of Continuing Medical Education (CME) at the Johns Hopkins University School of Medicine is committed to protecting the privacy of its members and customers. The Johns Hopkins University School of Medicine CME maintains its Internet site as an information resource and service for physicians, other health professionals and the public. Continuing Medical Education at the Johns Hopkins University School of Medicine will keep your personal and credit information confidential when you participate in a CME Internet-based program. Your information will never be given to anyone outside of the Johns Hopkins University School of Medicine's CME program. Continuing Medical Education collects only the information necessary to provide you with the services that you request.
AMERICANS WITH DISABILITIES ACT
The Johns Hopkins University School of Medicine fully complies with the legal requirements of the ADA and the rules and regulations thereof. Please notify us if you have any special needs.
To participate in additional CME activities presented by the Johns Hopkins University School of Medicine Continuing Medical Education Office, please visit
https://hopkinscme.cloud-cme.com
Technical Requirements
PC
Processor Speed: 1.4 GHz P4
Memory: 2 GB RAM (20MB available)
Operating Systems Supported: Windows 8 or greater
Browsers Supported: Internet Explorer 9 or greater, Mozilla Firefox and Chrome
Additional Requirements: Flash player 10.0 or greater, 1024 x 768 Resolution or higher with 32-bit color
Connection Speed: 2 Mbps or better
Adobe Acrobat 6.0 or greater
MAC
Processor Speed: G4 processor or higher
Memory: 2 GB RAM
Operating Systems Supported: OSX 10.7 or greater
Browsers Supported: Mozilla Firefox, Chrome and Safari 8 or greater
Additional Requirements: : Flash player 10.0 or greater
1024x768 Resolution or Higher with 32-bit color
Connection Speed: 512 Kbps or better
Adobe Acrobat 6.0 or greater
Technical Questions:
Please click on the Help button within the online player, or email MS-Leaders at support@ms-leaders.com
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